MIND

Brain Optimization: Cognitive Performance & Mental Sharpness

OTC · Available Now

Thorne Memoractiv

Interim bridge to future 4M cognitive SKU

Bacopa + ginkgo + magnesium-threonate + acetyl-L-tyrosine — practitioner-grade one-bottle multi-pathway cognitive stack. Stacks with Thorne Creatine at 5-10g/day for added cognitive benefit.

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Rx Protocol · By Consult

Cognitive consult — nootropic peptide candidacy

Lab-guided protocol for persistent memory, focus, and word-finding issues

Care coordinator connects you with a network physician for cognitive baseline assessment, hormone-cognition integration, and nootropic peptide candidacy (Semax, Selank, Cerebrolysin, BPC-157). Indicated when OTC alone hasn't moved the needle or when symptoms warrant a deeper workup.

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Why This Matters

Cognitive decline is reversible when caught early — the brain follows a ruthless use-it-or-lose-it principle
Chronic sleep debt, untreated gut inflammation, and hormonal decline are silently degrading neural architecture right now
Mind is the destination of the entire 4M framework — everything else feeds into cognitive output

What the research actually says — creatine for cognition

Most "premium nootropic" stacks ($60–100/month) are built on Bacopa, Lion's Mane, and proprietary blends with weak RCT support. The most-evidenced cognitive ingredient in the published literature is one most men only think of for the gym.

5g/day creatine for 6 weeks improved working memory and intelligence test performance. Double-blind, placebo-controlled, crossover trial. Working memory improved (P=.003); Raven's Advanced Progressive Matrices improved (P<.0001). Rae et al., Proc. Royal Society B, 2003. PubMed 14561278.
A single 25g creatine dose improved cognitive performance under sleep deprivation within 3 hours. Magnetic resonance spectroscopy showed measurable increases in cerebral high-energy phosphates. Brain phosphocreatine isn't theoretical — it's measurable, and it changes cognitive output. Gordji-Nejad et al., Scientific Reports, 2024. PubMed 38418482.
Beetroot juice (430mg dietary nitrate) increased cerebral blood flow during cognitive task performance and improved performance on demanding mental arithmetic. Cerebral perfusion declines ~0.4–0.5% per year in adulthood — improving endothelial NO is one of the few directly-actionable levers. Wightman et al., Physiology & Behavior, 2015. PubMed 26037632.

This is the underrated cognitive longevity story: the most-published nootropic ingredient in the peer-reviewed literature also happens to be the most-published lean-mass preservation ingredient. One supplement. Same physiology.

In development — Q4 2026

MitoVita

The four-pillar mitochondrial supplement most men have never heard of.

Once-daily formula: creatine monohydrate (5g), an NO-boosting blend (L-citrulline + standardized beetroot extract), and a functional electrolyte matrix. Sweetened with monk fruit only — fast-compatible.

One mechanism, four outcomes. Creatine is a mitochondrial ATP buffer; the NO blend delivers oxygen to those mitochondria via vasodilation. Mitochondrial function under adequate blood flow is the upstream node behind every age-related decline our demographic faces: cognitive function, lean-mass preservation, visceral-fat reduction, and sexual performance. Most men have heard of creatine for the gym. Almost none have heard about creatine for working memory, intelligence test performance, and resilience to sleep-deprived cognitive decline — all published in peer-reviewed research.

Formulation under clinical advisory board review. Manufacturing partner selection in progress.

How cognitive support touches all 4 Ms

Mind

Bioavailable B-vitamins your brain actually uses to make serotonin, dopamine, and GABA — the chemicals behind mood, focus, and calm. Creatine adds working memory and intelligence support on top.

Muscle

B-vitamins convert food into ATP — the energy your muscles run on. Creatine is the most-evidenced ingredient for lean-mass preservation past 40.

Mitigate

Methylated B-complex clears homocysteine — a top independent risk factor for heart disease and dementia. NO support from beetroot and citrulline maintains cerebral blood flow.

Motivate

Steady energy. Freedom from the low-grade fatigue and brain fog men accept as "just getting older."

Why you'll want this for life

Up to 60% of people carry genetic variants (MTHFR) that block standard B-vitamin conversion — a permanent feature of your biology. PPIs, metformin, and alcohol all deplete B-vitamins faster than diet replaces them. Cerebral blood flow declines about 0.4–0.5% per year in adulthood. Your body's ability to make creatine drops as you age, and dietary intake alone doesn't replace what your brain needs. The men who stop supporting these systems past 50 are accepting a decline trajectory they didn't have to accept.

Want the deeper protocol? The 4M Protégé program pairs your cognitive plan with the Connected Mind baseline assessment, daily Dual N-Back training, and ongoing coaching — all tracked in the My4MLife app. Learn about Protégé →

The Insulting Behaviors

Chronic poor sleep — the glymphatic system clears amyloid and metabolic waste during deep sleep only
Untreated gut inflammation — the gut-brain axis directly modulates neuroinflammation
No cognitive training — passive screen consumption makes no demands on the brain and drives atrophy
Excess alcohol — even moderate chronic use accelerates hippocampal atrophy

Take the Solution Path

Free Assessment

Find out exactly where you stand across all 4M pillars — 5 minutes, 10 questions, no card. The only door into the Protégé program and the My4MLife app.

Take the Free Assessment

Comprehensive 4M Consult

One consult, full review — see if you're a candidate for weight loss medication (GLP-1s), peptides, testosterone optimization, prescription protocols, practitioner-grade supplements, and the rest of your personalized 4M plan.

Weight loss medication candidacy (GLP-1s)
Testosterone & full hormone optimization (TRT, thyroid, peptides)
Nootropic peptides & cognitive support
Practitioner-grade supplement protocol
Prescription protocols & lab review

Schedule Your Comprehensive 4M Consult

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Become a Protégé — Free

Everything inside the program — included free once you take the assessment.

My4MLife app — daily 4M dashboard, action guide, adherence scorecard
Weekly Zooms with Dr. TJ and the cohort
The Cohort Workbook (PDF) and Begin with the End in Mind ebook
Cohort community
Personalized assessment results and care-coordinator pathway

Start the Free Assessment to Join →

"Begin with the end in mind."

— My4MLife

Medical Disclaimer: My4MLife provides access to telehealth services and prescription medications through licensed healthcare providers and pharmacies. Compounded medications are not FDA-approved. Individual results may vary. GLP-1 medications are prescription-only and require a physician evaluation. This website does not provide medical advice. Always consult with a qualified healthcare provider regarding your health. Testimonials reflect individual experiences and are not guarantees of results. Images may use models for privacy.